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Servable rate. Depending on the above assumptions, p(x, t), the probability at time t that the species are in state x can be represented as:R R X dp ; tX wr r r ; twr ; tdt r r6where p(xr, t) would be the probability of state change to x; wr(x) may be the propensity of no reaction occurring Equation (A6) is identified as the classic Chemical Master Equation (CME).two For integrating an ensem