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15] we propose a model in which SP-A regulates host defense function by both indirect and direct mechanisms. The indirect effects, as documented in this study, comprise a broad-based regulation of levels of expression of a number of BAL proteins important for innate immunity and host defense function. In the K. pneumoniae model employed here these deficits were rapidly reversed by the infectious c
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Radial migration assay was performed as previously described [30,31]. In a blinded fashion, various U87Gal-1 clones were analyzed and compared to U87GFP controls and parental U87MG cells. Of each clone, 2500 cells were allowed to sediment through a cooled manifold onto laminin-coated cell culture wells (Creative Scientific Methods, Inc., Phoenix, AZ). The manifold and slide were incubated together