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As the search model. The wild type SHP2 and D61G, E139D, Y279C and Q506P mutant structures were determined by molecular replacement, using the structure of the N308D SHP2 mutant as a search model. Following the initial rigid body refinement, interactive cycles of model building and refinement were performed by using COOT [40] and Buster-TNT [41] software. Special attention was paid to the mutation
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Late with DM, hyperlipidemia, smoking and FH. The combination of PAT and MAT correlated with MS and all the risk factors, except PVD, but did not correlate with CAD. (Data in Table 1.).O17 Prognostic significance of magnetic resonance imaging parameters in patients with idiopathic dilated cardiomyopathy Nico Merkle, Jan Torzewski, Georg Grossmann, Volker Rasche, Matthias Kochs, Jochen Woehrle and