Extracellular HMGB1 and its binding to RAGE seems necessary for mitochondrial ATP production and sustained cell growth.79 This study proposed that upon HMGB1 binding, RAGE translocates to the mitochondria, where it interacts with electron transport chain complexes I and II and thereby positively regulates oxidative phosphorylation. In addition, in the context of colorectal cancer, released HMGB1 c