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Concomitant using p53 induction, the increase in Necdin happened in addition to greater p21, a known p53-target gene (Amount 1b). Inversely, each time a prominent unfavorable peptide suppressant involving p53 exercise, GSE22 [29, 30], ended up being transduced throughout IMR90 utilizing a lentivirus construct, many of us observed any lower #links# in both Necdin as well as p21 necessary protein le